Bowel Cancer Faecal Occult Blood (FOB) / Transferrin GP/Pro Test 20 Tests Pack

Bowel Cancer Faecal Occult Blood (FOB) / Transferrin GP/Pro Test 20 Tests Pack

What is the Transferrin / FOB Combo Test?

Colorectal cancer is cancer that occurs in the colon or rectum, and affects both men and women of all racial and ethnic groups, and is most often found in people aged 50 years or older. For men, colorectal cancer is the third most common cancer after prostate and lung cancers. For women, colorectal cancer is the third most common cancer after breast and lung cancers. Fecal occult blood should be an important indicator in the diagnostic evaluation of patients with suspected gastrointestinal bleeding of any etiology, not just as an indication of colorectal cancer. The presence of human hemoglobin in faeces is inadequate as a screening test for stomach cancer (upper gastrointestinal disorders), because of human hemoglobin derived from the upper digestive tract is broken down in the intestinal tract (the antigenicity is lost). Detection of fecal transferrin, which is more stable in stool than hemoglobin, provides an alternative way of diagnosing the disease in the upper digestive tract. Blood in the stool may be the only symptom of cancer, but not all blood in the stool is caused by cancer. Other conditions that can cause blood in the stool include: Haemorrhoids, Anal fissures, Colon polyps, Peptic ulcers, Ulcerative colitis. Gastroesophageal reflux disease (GERD). Crohn’s disease, use of non-steroidal anti-inflammatory drugs (NSAIDs).

The Transferrin/FOB Combo Rapid Test Cassette (Faeces) is a qualitative, lateral flow immunoassay for the detection of human hemoglobin and transferrin in faeces. The membrane is precoated with anti-hemoglobin antibody and anti-transferrin antibody on the test line regions of the FOB and Transferrin. During testing, the specimen reacts with the particle coated with anti-hemoglobin antibody and/or anti-transferrin antibody. The mixture migrates upward on the membrane chromatographically by capillary action to react with antihemoglobin antibody and/or anti-transferrin antibody on the membrane and generate a colored line. The presence of this colored line in the test line region indicates a positive result, while its absence indicates a negative result. To serve as a procedural control, a colored line will always appear in the control line region, indicating that the proper volume of specimen has been added and membrane wicking has occurred.